Age-associated sensitivity to experimental, drug-induced marrow hypoplasia in laboratory rats
Language English Country Netherlands Media print
Document type Journal Article
PubMed
3692336
Knihovny.cz E-resources
- MeSH
- Abnormalities, Drug-Induced * MeSH
- Cyclophosphamide pharmacology MeSH
- Fluorenes pharmacology MeSH
- Bone Marrow abnormalities pathology MeSH
- Rats MeSH
- Lomustine pharmacology MeSH
- Lymphocytes pathology MeSH
- Disease Susceptibility MeSH
- Neutrophils pathology MeSH
- Cell Count drug effects MeSH
- Erythrocyte Count drug effects MeSH
- Reticulocytes pathology MeSH
- Aging physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cyclophosphamide MeSH
- Fluorenes MeSH
- Lomustine MeSH
- VUFB 13468 MeSH Browser
Treatment of adult rats of three age groups (8, 11 and 29 weeks) with haematotoxic doses of three different cytostatic agents (cyclophosphamide, 5-(2-dimethyl-aminoethoxy)-7-oxo-7H-benzo(c)fluorene, and lomustine) demonstrated a tendency to lower the sensitivity of elder animals to cytotoxic effects. The influence of age was especially distinct in changes of the reticulocyte or segmented neutrophil counts after all drugs tested. Changes in marrow nucleated erythroid cell counts were not significantly influenced by age. Reactions of other characteristics also depended on this factor but not following the administration of every drug.
