Saprophytic production of clavine alkaloids and activity of hydroxymethylglutaryl-CoA reductase
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
3770593
DOI
10.1007/bf02926952
Knihovny.cz E-zdroje
- MeSH
- Claviceps enzymologie metabolismus MeSH
- ergoliny biosyntéza MeSH
- hydroxymethylglutaryl-CoA-reduktasy metabolismus MeSH
- námelové alkaloidy biosyntéza MeSH
- steroly biosyntéza MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- agroclavine MeSH Prohlížeč
- chanoclavine MeSH Prohlížeč
- elymoclavine MeSH Prohlížeč
- ergoliny MeSH
- hydroxymethylglutaryl-CoA-reduktasy MeSH
- námelové alkaloidy MeSH
- steroly MeSH
In submerged Claviceps cultures the activity of hydroxymethylglutaryl-CoA reductase preceded the increase of alkaloid production and of sterol content. During the first alkaloid phase, cell mevalonate was involved in the biosynthesis of both alkaloids and steroids. In the second production phase, it was predominantly used for alkaloid synthesis. Hydroxymethylglutaryl-CoA reductase appears to be a suitable target for physiological manipulation to increase clavine alkaloid yields.
Zobrazit více v PubMed
Prog Nucleic Acid Res Mol Biol. 1970;10:57-86 PubMed
J Bacteriol. 1973 Apr;114(1):208-19 PubMed
J Biol Chem. 1983 Jan 10;258(1):378-85 PubMed
Biochem J. 1968 Jul;108(3):401-12 PubMed
Appl Environ Microbiol. 1984 Oct;48(4):826-9 PubMed
J Bacteriol. 1972 Nov;112(2):791-6 PubMed
Arch Biochem Biophys. 1976 Nov;177(1):84-94 PubMed
Metabolism. 1983 Mar;32(3):215-23 PubMed
J Gen Microbiol. 1970 Mar;60(3):403-15 PubMed
Physiological controls and regulation of ergot alkaloid formation
