Saprophytic production of clavine alkaloids and activity of hydroxymethylglutaryl-CoA reductase
Language English Country United States Media print
Document type Journal Article
PubMed
3770593
DOI
10.1007/bf02926952
Knihovny.cz E-resources
- MeSH
- Claviceps enzymology metabolism MeSH
- Ergolines biosynthesis MeSH
- Hydroxymethylglutaryl CoA Reductases metabolism MeSH
- Ergot Alkaloids biosynthesis MeSH
- Sterols biosynthesis MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- agroclavine MeSH Browser
- chanoclavine MeSH Browser
- elymoclavine MeSH Browser
- Ergolines MeSH
- Hydroxymethylglutaryl CoA Reductases MeSH
- Ergot Alkaloids MeSH
- Sterols MeSH
In submerged Claviceps cultures the activity of hydroxymethylglutaryl-CoA reductase preceded the increase of alkaloid production and of sterol content. During the first alkaloid phase, cell mevalonate was involved in the biosynthesis of both alkaloids and steroids. In the second production phase, it was predominantly used for alkaloid synthesis. Hydroxymethylglutaryl-CoA reductase appears to be a suitable target for physiological manipulation to increase clavine alkaloid yields.
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