The effect of bilirubin on the phagocytic activity of mouse peripheral granulocytes and monocytes in vivo
Language English Country United States Media print
Document type Journal Article
PubMed
4007709
Knihovny.cz E-resources
- MeSH
- Bilirubin pharmacology MeSH
- Time Factors MeSH
- Endotoxins blood MeSH
- Phagocytosis drug effects MeSH
- Granulocytes drug effects physiology MeSH
- Monocytes drug effects physiology MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Serum Albumin pharmacology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Bilirubin MeSH
- Endotoxins MeSH
- Serum Albumin MeSH
Using an in vitro phagocytic assay with synthetic 2-hydroxyethylmethacrylate copolymer particles, the phagocytic activity of leukocytes of bilirubin-treated mice (85 and 170 mumol/L in 0.5 mL intraperitoneally) was studied. Bilirubin treatment significantly stimulated the phagocytosis of both peripheral blood granulocytes and monocytes; the increase of phagocytosis persisted for 6 h after bilirubin injection. The potential immunostimulating and/or immunotoxic effect of bilirubin is discussed.
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The immunosuppressive effects of bilirubin
The stimulatory effect of bilirubin on phagocytic activity
