The suppressive effect of continuous infusion of bilirubin on the immune response in mice
Language English Country United States Media print
Document type Journal Article
PubMed
7192250
DOI
10.1007/bf02897214
Knihovny.cz E-resources
- MeSH
- Bilirubin pharmacology MeSH
- Cell Differentiation MeSH
- Cell Division MeSH
- Antibody-Producing Cells drug effects MeSH
- Immunosuppressive Agents * MeSH
- Mice, Inbred Strains MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Antibody Formation drug effects MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Bilirubin MeSH
- Immunosuppressive Agents * MeSH
Mice (strains Balb/c and A/J) received an intravenous infusion of bilirubin for a 1 d period. The infusion was delivered at various phases of the primary reaction; the degree of the immune response was expressed as the number of antibody-forming cells against sheep erythrocytes. Bilirubin infusion during both the inductive and productive phase of the primary reaction decreased significantly the immune response. We assume that bilirubin influences the differentiation of immunocompetent cells immediately after their contact with the antigen; in addition it acts in the period of the quantitative increase of the number of antibody-producing cells.
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