A study of the mechanism of lymphokine production and release
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
6155295
Knihovny.cz E-resources
- MeSH
- Cell Nucleus metabolism MeSH
- Phytohemagglutinins pharmacology MeSH
- Transplantation, Homologous MeSH
- Cells, Cultured MeSH
- Lymphocytes immunology physiology ultrastructure MeSH
- Lymphokines biosynthesis metabolism MeSH
- Mice MeSH
- Leukocyte Count MeSH
- Graft Survival MeSH
- RNA biosynthesis MeSH
- In Vitro Techniques MeSH
- Lymphocyte Culture Test, Mixed MeSH
- Transplantation, Isogeneic MeSH
- Skin Transplantation MeSH
- Rosette Formation MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Phytohemagglutinins MeSH
- Lymphokines MeSH
- RNA MeSH
The release of lymphokine, a "lymph node activating factor" is not accompanied by changes in the functions of lymphocytes bound on cell membrane, such as the capacity for E rosette formation, PHA responsiveness and induction of the transplantation reaction. Neither is it accompanied by nucleolar transformation which would suggest the changes in nucleolar RNA synthesis and protein synthesis. However, in mixed lymphocyte cultures from which the lymph node activating factor is released, the number of naked lymphocytes increases markedly.
