The effect of rifampicin on Mycobacterium smegmatis
Language English Country United States Media print
Document type Journal Article
PubMed
6177616
DOI
10.1007/bf02879764
Knihovny.cz E-resources
- MeSH
- Adenine metabolism MeSH
- Bacterial Proteins biosynthesis MeSH
- RNA, Bacterial biosynthesis MeSH
- DNA, Bacterial biosynthesis MeSH
- Glycine metabolism MeSH
- Leucine metabolism MeSH
- Mycobacterium drug effects metabolism MeSH
- Rifampin pharmacology MeSH
- Oxygen Consumption drug effects MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adenine MeSH
- Bacterial Proteins MeSH
- RNA, Bacterial MeSH
- DNA, Bacterial MeSH
- Glycine MeSH
- Leucine MeSH
- Rifampin MeSH
Rifampicin was found to inhibit the growth and incorporation of 14C-adenine, 14C-leucine and 14C-glycine in exponentially growing cells of M. smegmatic cultivated in Merrill's synthetic medium. Increasing concentrations of the antibiotic inhibited respiration in resting cells, in the presence of glucose or 2-oxoglutarate as substrates in particular. In addition to the well-known interference of rifampicin with the biosynthesis of RNA, the effect on the energy metabolism should also be considered.
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Folia Microbiol (Praha). 1980;25(5):403-11 PubMed
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Ann Inst Pasteur (Paris). 1971 Feb;120(2):186-95 PubMed
J Bacteriol. 1931 May;21(5):361-74 PubMed
Am Rev Respir Dis. 1971 Aug;104(2):272-4 PubMed
Biochim Biophys Acta. 1967;145(3):843-4 PubMed
Am Rev Respir Dis. 1972 Apr;105(4):519-27 PubMed
Bacteriol Rev. 1971 Sep;35(3):290-309 PubMed
