Effect of 2,3-dinitrilo-1,4-dithia-9,10-anthraquinone on Mycobacterium smegmatis
Language English Country United States Media print
Document type Journal Article
PubMed
7429371
DOI
10.1007/bf02876693
Knihovny.cz E-resources
- MeSH
- Acetates metabolism MeSH
- Anthraquinones pharmacology MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Glucose metabolism MeSH
- Ketoglutaric Acids metabolism MeSH
- Mycobacterium drug effects growth & development metabolism MeSH
- Nitriles pharmacology MeSH
- Oxygen Consumption drug effects MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Acetates MeSH
- Anthraquinones MeSH
- Anti-Bacterial Agents MeSH
- dithianone MeSH Browser
- Glucose MeSH
- Ketoglutaric Acids MeSH
- Nitriles MeSH
2,3-Dinitrilo-1,4-dithia-9,10-anthraquinone (DDA) is an effective inhibitor of respiration of intact cells of Mycobacterium smegmatis in the presence of glucose, glycerol, pyruvate, acetate and other citric acid cycle intermediates or substrates associated with this cyclic (glutamate, asparagine). DDA inhibits the incorporation of both 14C-leucine and 14C-adenine into appropriate macromolecules of M. smegmatis (TCA-precipitable fractions), and causes a drop in the incorporated activity of U-14C-glycine or its degradation products in all the cell fractions studied (lipids, RNA, DNA, proteins). DDA suppresses the growth of M. smegmatis probably through an interference with the cell energy-carbon metabolism.
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