Inhibition of the incorporation of 14C-precursors in Mycobacterium smegmatis by antibiotics and chemotherapeutics
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
7061029
DOI
10.1007/bf02883837
Knihovny.cz E-zdroje
- MeSH
- adenin metabolismus MeSH
- antituberkulotika farmakologie MeSH
- antituberkulózní antibiotika farmakologie MeSH
- kultivační média MeSH
- leucin metabolismus MeSH
- Mycobacterium účinky léků metabolismus MeSH
- radioizotopy uhlíku MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adenin MeSH
- antituberkulotika MeSH
- antituberkulózní antibiotika MeSH
- kultivační média MeSH
- leucin MeSH
- radioizotopy uhlíku MeSH
Twenty antituberculostatics and twelve other compounds were divided into three groups according to their ability to influence the rate of incorporation of 14C-adenine and 14C-leucine in M. smegmatis. The first group includes compounds significantly inhibiting the incorporation of 14C-leucine, the second group comprises compounds inhibiting simultaneously the incorporation of both 14C-precursors, the third group contains compounds that do not bring about a 50% decrease of the rate of incorporation even at a concentration of 400 micrograms/mL.
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