Inhibition of the incorporation of 14C-precursors in Mycobacterium smegmatis by antibiotics and chemotherapeutics
Language English Country United States Media print
Document type Journal Article
PubMed
7061029
DOI
10.1007/bf02883837
Knihovny.cz E-resources
- MeSH
- Adenine metabolism MeSH
- Antitubercular Agents pharmacology MeSH
- Antibiotics, Antitubercular pharmacology MeSH
- Culture Media MeSH
- Leucine metabolism MeSH
- Mycobacterium drug effects metabolism MeSH
- Carbon Radioisotopes MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adenine MeSH
- Antitubercular Agents MeSH
- Antibiotics, Antitubercular MeSH
- Culture Media MeSH
- Leucine MeSH
- Carbon Radioisotopes MeSH
Twenty antituberculostatics and twelve other compounds were divided into three groups according to their ability to influence the rate of incorporation of 14C-adenine and 14C-leucine in M. smegmatis. The first group includes compounds significantly inhibiting the incorporation of 14C-leucine, the second group comprises compounds inhibiting simultaneously the incorporation of both 14C-precursors, the third group contains compounds that do not bring about a 50% decrease of the rate of incorporation even at a concentration of 400 micrograms/mL.
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