Isolated fractions of the growth-promoting alpha-globulin stimulate differently the incorporation of exogenous DNA into L cells
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
6183151
Knihovny.cz E-zdroje
- MeSH
- alfa-globuliny farmakologie MeSH
- biologický transport účinky léků MeSH
- DNA metabolismus MeSH
- kinetika MeSH
- L buňky (buněčná linie) účinky léků metabolismus MeSH
- myši MeSH
- tritium MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- alfa-globuliny MeSH
- DNA MeSH
- tritium MeSH
The growth-promoting alpha-globulin necessary for long-term cultivation of mammalian cells in serum-free medium is a complex of several proteins which also stimulates the incorporation of exogenous DNA into recipient L cells. Biological activity responsible for the stimulation of DNA incorporation into L cells can be concentrated because one of two major protein components, compared to the whole GPAG complex, increases incorporation into cell nuclei by 100%.