Cell cycle in Mycobacterium phlei
Language English Country United States Media print
Document type Journal Article
PubMed
6378738
DOI
10.1007/bf02877307
Knihovny.cz E-resources
- MeSH
- Chromosomes, Bacterial MeSH
- Cell Cycle MeSH
- Time Factors MeSH
- DNA, Bacterial biosynthesis MeSH
- Escherichia coli cytology MeSH
- Nalidixic Acid pharmacology MeSH
- Mycobacterium phlei cytology genetics MeSH
- Mycobacterium cytology MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- DNA, Bacterial MeSH
- Nalidixic Acid MeSH
The initial replication region of the chromosome on the replication map of M. phlei constructed by means of sequential mutagenesis in synchronous populations was accurately determined. By following the time shift of the replication moment of the genes bac and met in the control culture and in the culture with the initial inhibition of DNA synthesis by nalidixic acid the start of replication of the chromosome was determined at 15 min before replication of the gene ile. On the basis of the results obtained a scheme of the cell cycle in M. phlei was proposed. Intervals C and D depend on the generation time, become prolonged independently of each other and assume the whole cycle. The ratio C/(C + D) equals to 0.56 and the interval D has a value of 0.76 of the interval C. The mutual ratio of the intervals C : D is 1.3 : 1.0. The obtained results make it possible to form the assumption about mutual ratios between the chromosome replication and cell division in bacteria exhibiting slow growth rates.
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Mycobacteria in the light of modern genetics development