Experimental infection of sheep with Bhanja virus
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
6425154
Knihovny.cz E-resources
- MeSH
- Ataxia veterinary MeSH
- Bunyaviridae immunology MeSH
- Bunyaviridae Infections immunology microbiology physiopathology veterinary MeSH
- Disease Susceptibility MeSH
- Sheep Diseases immunology microbiology MeSH
- Sheep MeSH
- Paresis veterinary MeSH
- Antibodies, Viral biosynthesis MeSH
- Viremia veterinary MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antibodies, Viral MeSH
Seven juvenile sheep were infected subcutaneously (s.c.) or intracerebrally (i.c.) with Bhanja virus. Distinct symptoms of CNS affection (ataxia, pareses) were observed only in the case of i.c. application of a massive dose (10(-7) to 10(9) SMicLD50) of the Bg 336/336 strain. A short-term and low viremia (one to four days p.i.) was ascertained after i.c. infection with a dose of 10(4.7) to 10(9.2) SMicLD50 of the same strain. On the other hand, the high titres of neutralization antibodies were detected even after inoculation of small doses of the virus (e.g. 50 SMicLD50). Unlike the symptomatic response, the immune response of sheep to Bhanja virus is high.
Biogeography of tick-borne bhanja virus (bunyaviridae) in europe
