Isolation, characterization and biological activities of verotetrone from a mutant strain of Streptomyces aureofaciens
Language English Country United States Media print
Document type Journal Article
PubMed
6774935
DOI
10.1007/bf02876607
Knihovny.cz E-resources
- MeSH
- Anthracyclines * MeSH
- Bacteria drug effects MeSH
- Candida drug effects MeSH
- Carcinoma, Ehrlich Tumor metabolism MeSH
- Leukemia, Experimental drug therapy immunology MeSH
- Neoplasms, Experimental MeSH
- Mice, Inbred Strains MeSH
- Mutation MeSH
- Mice MeSH
- Naphthacenes analysis isolation & purification pharmacology MeSH
- Nucleic Acids biosynthesis MeSH
- Antibiotics, Antineoplastic * MeSH
- Streptomyces aureofaciens metabolism MeSH
- Transplantation Immunology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anthracyclines * MeSH
- Naphthacenes MeSH
- Nucleic Acids MeSH
- Antibiotics, Antineoplastic * MeSH
- verotetrone MeSH Browser
A new metabolite denoted as verotetrone was isolated from the mycelium of the mutant strain Streptomyces aureofaciens NMG-2. Interpretations of physical data concerning verotetrone and its triacetate and, the determination of its degradation product indicate that verotetrone belongs to pretetramide-type metabolites. Verotetrone exhibits neither antibacterial nor antifungal activity. In vitro it inhibits the synthesis of nucleic acids as well as proteins in Ehrlich ascites carcinoma cells. Both verotetrone and its triacetate interfere in vivo with the metabolism of tumour and lymphoid cells, exhibiting antitumour or immunosuppressive activity. This activity, which is more intense with verotetrone than with its triacetate, is detectable in a dose which is already toxic in some animals.
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