Isolation, characterization and biological activities of verotetrone from a mutant strain of Streptomyces aureofaciens
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
6774935
DOI
10.1007/bf02876607
Knihovny.cz E-zdroje
- MeSH
- antracykliny * MeSH
- Bacteria účinky léků MeSH
- Candida účinky léků MeSH
- Ehrlichův tumor metabolismus MeSH
- experimentální leukemie farmakoterapie imunologie MeSH
- experimentální nádory MeSH
- inbrední kmeny myší MeSH
- mutace MeSH
- myši MeSH
- naftaceny analýza izolace a purifikace farmakologie MeSH
- nukleové kyseliny biosyntéza MeSH
- protinádorová antibiotika * MeSH
- Streptomyces aureofaciens metabolismus MeSH
- transplantační imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antracykliny * MeSH
- naftaceny MeSH
- nukleové kyseliny MeSH
- protinádorová antibiotika * MeSH
- verotetrone MeSH Prohlížeč
A new metabolite denoted as verotetrone was isolated from the mycelium of the mutant strain Streptomyces aureofaciens NMG-2. Interpretations of physical data concerning verotetrone and its triacetate and, the determination of its degradation product indicate that verotetrone belongs to pretetramide-type metabolites. Verotetrone exhibits neither antibacterial nor antifungal activity. In vitro it inhibits the synthesis of nucleic acids as well as proteins in Ehrlich ascites carcinoma cells. Both verotetrone and its triacetate interfere in vivo with the metabolism of tumour and lymphoid cells, exhibiting antitumour or immunosuppressive activity. This activity, which is more intense with verotetrone than with its triacetate, is detectable in a dose which is already toxic in some animals.
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