Mutagenic effects of allylisothiocyanate in Escherichia coli WP 67
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
7037578
DOI
10.1007/bf02883833
Knihovny.cz E-zdroje
- MeSH
- aktivace enzymů MeSH
- Cercopithecus aethiops MeSH
- Cricetulus MeSH
- Escherichia coli účinky léků MeSH
- inbrední kmeny potkanů MeSH
- isothiokyanatany * MeSH
- jaterní mikrozomy účinky léků enzymologie metabolismus MeSH
- kozy MeSH
- křečci praví MeSH
- krysa rodu Rattus MeSH
- mutageny * metabolismus MeSH
- myši MeSH
- techniky in vitro MeSH
- testy genotoxicity MeSH
- thiokyanatany metabolismus farmakologie MeSH
- zvířata MeSH
- Check Tag
- křečci praví MeSH
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- allyl isothiocyanate MeSH Prohlížeč
- isothiokyanatany * MeSH
- mutageny * MeSH
- thiokyanatany MeSH
A mutagenic effect of allylisothiocyanate (AITC) on E. coli WP 67 (trp uvrA polA) was only found in a test with metabolic activation in vitro. Mixed function oxidases containing cytochrome P-450 are not responsible for the conversion of AITC to mutagenic products. Liver microsomal fractions of rat, mouse, chinese hamster, goat and monkey were used for in vitro metabolic activation. The mutagenic effect of AITC differed in individual animal species according to the protein content in the microsomal fraction. Allylamine (formed by hydrolysis of AITC) did not exhibit any mutagenic effect.
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Antibacterial and mutagenic activities of new isothiocyanate derivatives
