Antibacterial and mutagenic activities of new isothiocyanate derivatives
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
11501396
DOI
10.1007/bf02873587
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky chemie farmakologie MeSH
- isothiokyanatany chemie farmakologie toxicita MeSH
- krysa rodu Rattus MeSH
- mikrobiální testy citlivosti MeSH
- mutageny chemie toxicita MeSH
- potkani Wistar MeSH
- Salmonella typhimurium účinky léků MeSH
- testy genotoxicity MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antibakteriální látky MeSH
- isothiokyanatany MeSH
- mutageny MeSH
Nine newly synthesized isothiocyanate derivatives were demonstrated to posses antibacterial and genotoxic activities in vitro. 4-Hydroxybutyl isothiocyanate exhibited a broad antibacterial effect, with MIC values of 762 mumol/L for Staphylococcus aureus and Escherichia coli. Ethyl 4-methylsulfoxidobutanoate had the highest antibacterial activity in Gram-positive bacteria, the MIC value being 425 mumol/L for S. aureus. The highest tested concentrations of ethyl 4-isothiocyanatobutanoate and 4-hydroxybutyl isothiocyanate produced a bacteriocidal effect in Gram-positive bacteria. The compounds showed no mutagenic effects on Salmonella typhimurium tester strains TA 98 and TA 100, either in the absence or in the presence of a metabolically active microsomal S9 fraction from rat liver using standard Ames test.
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Biosci Biotechnol Biochem. 1998 Feb;62(2):363-5 PubMed
Cancer Res. 1998 Oct 15;58(20):4632-9 PubMed
Biochem Soc Trans. 1996 Aug;24(3):806-10 PubMed
Folia Microbiol (Praha). 1982;27(1):25-31 PubMed
Folia Microbiol (Praha). 1995;40(6):611-4 PubMed
Gan. 1982 Apr;73(2):255-63 PubMed
Neoplasma. 1971;18(4):355-9 PubMed
Appl Microbiol. 1967 Jul;15(4):701-9 PubMed
Mutat Res. 1985 Apr-May;156(1-2):33-7 PubMed
J Cell Biochem Suppl. 1995;22:195-209 PubMed
Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):733-48 PubMed
Biosci Biotechnol Biochem. 1998 Mar;62(3):491-5 PubMed
Mutat Res. 1983 May;113(3-4):173-215 PubMed
Crit Rev Food Sci Nutr. 1983;18(2):123-201 PubMed
Folia Microbiol (Praha). 1985;30(4):359-62 PubMed
