Antibacterial and mutagenic activities of new isothiocyanate derivatives
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11501396
DOI
10.1007/bf02873587
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Isothiocyanates chemistry pharmacology toxicity MeSH
- Rats MeSH
- Microbial Sensitivity Tests MeSH
- Mutagens chemistry toxicity MeSH
- Rats, Wistar MeSH
- Salmonella typhimurium drug effects MeSH
- Mutagenicity Tests MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Isothiocyanates MeSH
- Mutagens MeSH
Nine newly synthesized isothiocyanate derivatives were demonstrated to posses antibacterial and genotoxic activities in vitro. 4-Hydroxybutyl isothiocyanate exhibited a broad antibacterial effect, with MIC values of 762 mumol/L for Staphylococcus aureus and Escherichia coli. Ethyl 4-methylsulfoxidobutanoate had the highest antibacterial activity in Gram-positive bacteria, the MIC value being 425 mumol/L for S. aureus. The highest tested concentrations of ethyl 4-isothiocyanatobutanoate and 4-hydroxybutyl isothiocyanate produced a bacteriocidal effect in Gram-positive bacteria. The compounds showed no mutagenic effects on Salmonella typhimurium tester strains TA 98 and TA 100, either in the absence or in the presence of a metabolically active microsomal S9 fraction from rat liver using standard Ames test.
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