Antitrichomonadal and other biological effects of sugar hydrazones and phenylosazones
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
7061030
DOI
10.1007/bf02883838
Knihovny.cz E-zdroje
- MeSH
- antitrichomonádové látky farmakologie toxicita MeSH
- Ehrlichův tumor farmakoterapie metabolismus MeSH
- hydrazony farmakologie MeSH
- myši MeSH
- protinádorové látky farmakologie MeSH
- sacharidy farmakologie MeSH
- skot MeSH
- techniky in vitro MeSH
- testy genotoxicity MeSH
- Trichomonas účinky léků růst a vývoj MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antitrichomonádové látky MeSH
- hydrazony MeSH
- protinádorové látky MeSH
- sacharidy MeSH
When investigating the possible antitrichomodal effect of 41 phenylsazones, nitro- and dinitro-phenylhydrazones a significant inhibitory effect on multiplication of Trichomonas foetus could be detected in 14 derivatives; eight derivatives were ineffective, other derivatives exhibited only a slight effect. The inhibitory effect of most compounds increased after acetylation. Toxicity of seven effective compounds was determined in vivo. Mutagenicity of these compounds was followed with microorganisms and their cytotoxicity with tumor EAC cells. Two of the effective compounds exhibited also a significant mutagenic effect, three of eight compounds had a pronounced cytotoxic effect, three of eight compounds had a pronounced cytotoxic effect in vitro on the EAC cells, in which they inhibited mainly the incorporation of adenine.
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