Antitrichomonadal and other biological effects of sugar hydrazones and phenylosazones
Language English Country United States Media print
Document type Journal Article
PubMed
7061030
DOI
10.1007/bf02883838
Knihovny.cz E-resources
- MeSH
- Antitrichomonal Agents pharmacology toxicity MeSH
- Carcinoma, Ehrlich Tumor drug therapy metabolism MeSH
- Hydrazones pharmacology MeSH
- Mice MeSH
- Antineoplastic Agents pharmacology MeSH
- Carbohydrates pharmacology MeSH
- Cattle MeSH
- In Vitro Techniques MeSH
- Mutagenicity Tests MeSH
- Trichomonas drug effects growth & development MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Cattle MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antitrichomonal Agents MeSH
- Hydrazones MeSH
- Antineoplastic Agents MeSH
- Carbohydrates MeSH
When investigating the possible antitrichomodal effect of 41 phenylsazones, nitro- and dinitro-phenylhydrazones a significant inhibitory effect on multiplication of Trichomonas foetus could be detected in 14 derivatives; eight derivatives were ineffective, other derivatives exhibited only a slight effect. The inhibitory effect of most compounds increased after acetylation. Toxicity of seven effective compounds was determined in vivo. Mutagenicity of these compounds was followed with microorganisms and their cytotoxicity with tumor EAC cells. Two of the effective compounds exhibited also a significant mutagenic effect, three of eight compounds had a pronounced cytotoxic effect, three of eight compounds had a pronounced cytotoxic effect in vitro on the EAC cells, in which they inhibited mainly the incorporation of adenine.
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