Antineutrophil cytoplasmic antibody-positive sera inhibit candidacidal activity of granulocytes
Language English Country Switzerland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
7712143
Knihovny.cz E-resources
- MeSH
- Autoantibodies immunology MeSH
- Candida albicans * MeSH
- Adult MeSH
- Granulomatosis with Polyangiitis immunology microbiology pathology MeSH
- Candidiasis immunology microbiology pathology MeSH
- Cells, Cultured MeSH
- Middle Aged MeSH
- Humans MeSH
- Neutrophils immunology MeSH
- Antibodies, Antineutrophil Cytoplasmic MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Autoantibodies MeSH
- Antibodies, Antineutrophil Cytoplasmic MeSH
Antineutrophil cytoplasmic antibodies (ANCA) are suspected of being involved in the pathogenesis of tissue injury in systemic vasculitis. We have investigated the effect of 10 sera from 8 patients with ANCA-associated diseases on the capacity of neutrophils derived from healthy persons to kill ingested Candida albicans. ANCA-containing sera inhibited candidacidal activity by 55-80% in comparison to control sera. This phenomenon could lead to the depression of antimicrobial resistance of patients with ANCA and could be involved in the pathogenesis of granuloma formation.
