The polybacterial lysate Olimunostim modulates lymphocyte function in vitro and restores depressed cellular immunity in vivo
Language English Country United States Media print
Document type Journal Article
PubMed
7729777
DOI
10.1007/bf02814452
Knihovny.cz E-resources
- MeSH
- Adjuvants, Immunologic metabolism pharmacology MeSH
- Lymphocyte Activation MeSH
- Immunity, Cellular * MeSH
- Interleukin-2 biosynthesis MeSH
- Klebsiella pneumoniae metabolism MeSH
- Concanavalin A pharmacology MeSH
- Lymphocytes immunology MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Propionibacterium acnes metabolism MeSH
- Staphylococcus aureus metabolism MeSH
- Immunologic Deficiency Syndromes immunology therapy MeSH
- T-Lymphocytes immunology MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adjuvants, Immunologic MeSH
- Interleukin-2 MeSH
- Concanavalin A MeSH
Immunobiological activity of the polybacterial lysate Olimunostim (P. acnes, K. pneumoniae, S. aureus) was examined by investigating its effects on murine lymphocytes. When added to in vitro lymphocyte cultures, Olimunostim induced interleukin-2 (IL-2) biological activity (in a 2-d culture) and subsequently potentiated lymphocyte proliferation (on day 3); the latter effect was dependent on the presence of adherent cells. In vivo, significant enhancement of lymphocyte reactivity to T-mitogens and increase of CD4+ helper-inducer T lymphocytes were observed 3 d after a subcutaneous application of Olimunostim to mice with cellular immune deficiency. These results confirm the modulatory properties of Olimunostim towards lymphocytes both in vitro and in vivo, which may form a basis for its clinical application.
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