The polybacterial lysate Olimunostim modulates lymphocyte function in vitro and restores depressed cellular immunity in vivo
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
7729777
DOI
10.1007/bf02814452
Knihovny.cz E-zdroje
- MeSH
- adjuvancia imunologická metabolismus farmakologie MeSH
- aktivace lymfocytů MeSH
- buněčná imunita * MeSH
- interleukin-2 biosyntéza MeSH
- Klebsiella pneumoniae metabolismus MeSH
- konkanavalin A farmakologie MeSH
- lymfocyty imunologie MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- Propionibacterium acnes metabolismus MeSH
- Staphylococcus aureus metabolismus MeSH
- syndromy imunologické nedostatečnosti imunologie terapie MeSH
- T-lymfocyty imunologie MeSH
- techniky in vitro MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adjuvancia imunologická MeSH
- interleukin-2 MeSH
- konkanavalin A MeSH
Immunobiological activity of the polybacterial lysate Olimunostim (P. acnes, K. pneumoniae, S. aureus) was examined by investigating its effects on murine lymphocytes. When added to in vitro lymphocyte cultures, Olimunostim induced interleukin-2 (IL-2) biological activity (in a 2-d culture) and subsequently potentiated lymphocyte proliferation (on day 3); the latter effect was dependent on the presence of adherent cells. In vivo, significant enhancement of lymphocyte reactivity to T-mitogens and increase of CD4+ helper-inducer T lymphocytes were observed 3 d after a subcutaneous application of Olimunostim to mice with cellular immune deficiency. These results confirm the modulatory properties of Olimunostim towards lymphocytes both in vitro and in vivo, which may form a basis for its clinical application.
Zobrazit více v PubMed
Bratisl Lek Listy. 1989 Oct;90(10):719-31 PubMed
Immunopharmacol Immunotoxicol. 1989;11(1):17-32 PubMed
Acta Univ Palacki Olomuc Fac Med. 1992;134:55-9 PubMed
J Immunol. 1978 Jun;120(6):2027-32 PubMed
Lung. 1990;168 Suppl:707-15 PubMed
Arzneimittelforschung. 1980;30(1a):198-206 PubMed
Zentralbl Bakteriol. 1990 Apr;272(4):467-76 PubMed
Int J Immunopharmacol. 1990;12(1):11-8 PubMed
Folia Microbiol (Praha). 1991;36(2):99-111 PubMed
Immunopharmacol Immunotoxicol. 1990;12(1):123-33 PubMed
Folia Microbiol (Praha). 1991;36(2):192-7 PubMed
Lung. 1990;168 Suppl:732-6 PubMed
Clin Exp Immunol. 1987 Oct;70(1):201-8 PubMed
