High-performance liquid chromatographic determination of terguride in solid dosage forms and plasma
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
PubMed
7735478
DOI
10.1016/0378-4347(94)00438-b
PII: 037843479400438B
Knihovny.cz E-zdroje
- MeSH
- agonisté dopaminu analýza krev MeSH
- krysa rodu Rattus MeSH
- lisurid analogy a deriváty analýza krev MeSH
- námelové alkaloidy izolace a purifikace MeSH
- tablety MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- agonisté dopaminu MeSH
- dironyl MeSH Prohlížeč
- lisurid MeSH
- námelové alkaloidy MeSH
- tablety MeSH
A simple and rapid HPLC method was developed to determine terguride in terguride hydrogenmaleate, coated tablets and plasma. The assay was carried out on a glass column of SGX CN (150 x 3.3 mm I.D.) using methanol and phosphate buffer solution (pH 7.0) as the mobile phase, with detection at 227 nm. Terguride was quantified using promethazine as an internal standard. The tablet matrix was extracted into methanol. Plasma samples were deproteinated with acetonitrile and the supernatant was injected into the HPLC system. The method is linear, quantitative and reproducible.
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