Dicarbanonaborates--new inhibitors of mitochondrial L-glycerol-3-phosphate dehydrogenase
Language English Country United States Media print
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
7763250
DOI
10.1006/bbrc.1995.1724
PII: S0006-291X(85)71724-X
Knihovny.cz E-resources
- MeSH
- Borates chemical synthesis chemistry pharmacology MeSH
- Glycerolphosphate Dehydrogenase antagonists & inhibitors MeSH
- Adipose Tissue, Brown enzymology MeSH
- Enzyme Inhibitors chemical synthesis chemistry pharmacology MeSH
- Kinetics MeSH
- Cricetinae MeSH
- Mesocricetus MeSH
- Mitochondria enzymology MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Cricetinae MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- Borates MeSH
- Glycerolphosphate Dehydrogenase MeSH
- Enzyme Inhibitors MeSH
The inhibitory effect of mercapto- and chlorodicarbanonaborates on mitochondrial, FAD-linked, L-glycerol-3-phosphate dehydrogenase activity was tested. The mercaptodicarbanonaborate was found to be a more potent inhibitor than the chloro derivative. The Ki of mercapto- and chlorodicarbanonaborates were 0.8 M and 480 M, respectively. Whereas the mercaptodicarbanonaborate inhibited the enzyme activity competitively, the inhibitory effect of chloro derivative was noncompetitive. The inhibitory effect of mercaptodicarbanonaborate was completely prevented by addition of bovine serum albumin.
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