Fytoterapeutické aspekty onemocnĕní obĕhového systému. III. Kardiotonický a kardiotoxický úcinek hyrkanosidu a deglukohyrkanosidu izolovaných z Coronilla varia L
[Phytotherapeutic aspects of diseases of the circulatory system. III. Cardiotonic and cardiotoxic effects of hyrcanoside and deglucohyrcanoside isolated from Coronilla varia L]
Language Czech Country Czech Republic Media print
Document type Comparative Study, English Abstract, Journal Article
PubMed
7812688
- MeSH
- Digoxin pharmacology MeSH
- Guinea Pigs MeSH
- Ouabain pharmacology MeSH
- Plant Extracts pharmacology toxicity MeSH
- Heart drug effects MeSH
- Cardiac Glycosides pharmacology toxicity MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Male MeSH
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- deglucohyrcanoside MeSH Browser
- Digoxin MeSH
- hyrcanoside MeSH Browser
- Ouabain MeSH
- Plant Extracts MeSH
- Cardiac Glycosides MeSH
The Cardiotonic and cardiotoxic effects of two cardiac glycosides-hyrcanoside and deglucohyrcanoside-isolated from the seeds of Coronilla varia L. were evaluated in the paper--in comparison with the effect and toxicity of digoxin and ouabain. Evaluation of the cardiotonic effect using the methods of heart "in situ" and the isolated heart (Langendorff) proved that deglucohyrcanoside is more effective than hyrcanoside and that its effect is equal to that of digoxin as well as ouabain. The efficacy of deglucohyrcanoside et least to that of digoxin, while the toxicity of the former is several times lower, makes the glycoside a potential candidate for therapeutic use.
