Serum antibody profiles of Sarcoptes scabiei infested or immunized rabbits
Language English Country Czech Republic Media print
Document type Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.
Grant support
A1 17252
PHS HHS - United States
PubMed
7883255
Knihovny.cz E-resources
- MeSH
- Antigens analysis MeSH
- Immunoelectrophoresis, Two-Dimensional MeSH
- Rabbits MeSH
- Antibodies blood MeSH
- Sarcoptes scabiei immunology MeSH
- Scabies immunology MeSH
- Tissue Extracts immunology MeSH
- Vaccination MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Comparative Study MeSH
- Names of Substances
- Antigens MeSH
- Antibodies MeSH
- Tissue Extracts MeSH
The circulating antibody profiles of rabbits infected or immunized with Sarcoptes scabiei var. canis were compared. Crossed immuno-electrophoretic analysis showed that infested hosts produced serum antibody to 12 proteins (antigens) in an extract made from sarcoptic mite bodies. In contrast, rabbits immunized with an extract made from mite bodies produced antibody to 20 Sarcoptes proteins (antigens). SDS-PAGE/immunoblot analysis revealed that serum from immunized rabbits contained antibodies that bound strongly to proteins of 25 and 39-52 kD that were only barely visualized by antibodies in serum from infested rabbits.
