Humoral and cellular immune response of BALB/c mice to repeated infestations with Ixodes ricinus nymphs
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
8021100
DOI
10.1016/0020-7519(94)90066-3
PII: 0020-7519(94)90066-3
Knihovny.cz E-zdroje
- MeSH
- aktivace lymfocytů MeSH
- buněčná imunita MeSH
- infestace klíšťaty imunologie MeSH
- klíšťata imunologie MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- nymfa imunologie MeSH
- organismy bez specifických patogenů MeSH
- tvorba protilátek MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The capacity of female BALB/c mice to mount an immune response and effective resistance to repeated infestations with I. ricinus nymphs was studied. An anamnestic antibody response and transient in vitro responsiveness of spleen lymphocytes to tick antigens were demonstrated in repeatedly infested mice. On the other hand, the response to concanavalin A--a T-cell mitogen, was suppressed at the same time. In the presented experiment, BALB/c mice did not manifest tick resistance after three successive infestations (with a reinfestation period of 2 weeks). The possibility of an infestation-dependent modulation of immune response in BALB/c mice is discussed.
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