Distribution of 11 beta-hydroxysteroid dehydrogenase along the rat intestine
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
8107525
DOI
10.1016/0024-3205(94)90164-3
PII: 0024-3205(94)90164-3
Knihovny.cz E-zdroje
- MeSH
- 11-beta-hydroxysteroiddehydrogenasy MeSH
- adrenalektomie MeSH
- aldosteron metabolismus MeSH
- cékum enzymologie MeSH
- duodenum enzymologie MeSH
- hydroxysteroiddehydrogenasy analýza antagonisté a inhibitory metabolismus MeSH
- jejunum enzymologie MeSH
- karbenoxolon farmakologie MeSH
- kolon enzymologie MeSH
- kortikosteron analogy a deriváty biosyntéza metabolismus MeSH
- krysa rodu Rattus MeSH
- potkani Wistar MeSH
- receptory mineralokortikoidů analýza metabolismus MeSH
- sodík metabolismus MeSH
- střeva enzymologie MeSH
- střevní sliznice enzymologie MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 11-beta-hydroxysteroiddehydrogenasy MeSH
- 11-dehydrocorticosterone MeSH Prohlížeč
- aldosteron MeSH
- hydroxysteroiddehydrogenasy MeSH
- karbenoxolon MeSH
- kortikosteron MeSH
- receptory mineralokortikoidů MeSH
- sodík MeSH
Aldosterone selectivity of mineralocorticoid target tissues has been suggested to be due to the inactivation of glucocorticoids in the target tissue by 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD). The distribution of 11 beta-OHSD was studied in the intestine which is composed of aldosterone-sensitive and insensitive segments. The activity of the enzyme was high in distal colon and medium in ileum, cecum, and proximal colon. Zero activity was found in duodenum and jejunum. Carbenoxolone completely blocked the enzyme. Low-salt diet increased the activity in proximal colon and decreased in ileum. Adrenalectomy decreased the activity in ileum and proximal colon. The existence of segmental differences in the distribution of 11 beta-OHSD and the hormonal effect on the activity of the enzyme suggest a physiological role of 11 beta-OHSD in the intestine.
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