Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8157135
Knihovny.cz E-resources
- MeSH
- Adenine analogs & derivatives therapeutic use MeSH
- Leukemia-Lymphoma, Adult T-Cell drug therapy MeSH
- Leukemia, Experimental drug therapy MeSH
- Rats MeSH
- Leukemic Infiltration MeSH
- Organophosphonates * MeSH
- Rats, Sprague-Dawley MeSH
- Antineoplastic Agents therapeutic use MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- adefovir MeSH Browser
- Adenine MeSH
- Organophosphonates * MeSH
- Antineoplastic Agents MeSH
Two cases of spontaneous acute lymphoblastic leukemia in the inbred strain of Sprague-Dawley (Prague) rats have been observed. Since its reliable transplantability in syngeneic recipients was established, leukemic animals were used to test the cytostatic effect of PMEA. The treatment resulted in a significant prolongation of survival time of the treated animals. At the same time histological examination of PMEA-treated and untreated animals indicated that the drug effectively slows down the growth of lymphoma at the site of inoculation and inhibits the subsequent progression of tumor cells in the lung, liver, spleen and lymph nodes.
