Cerebral energy state of neonatal rats during seizures induced by homocysteine
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8218146
Knihovny.cz E-resources
- MeSH
- Adenosine Triphosphate metabolism MeSH
- Energy Metabolism physiology MeSH
- Phosphocreatine metabolism MeSH
- Glucose metabolism MeSH
- Glycogen metabolism MeSH
- Homocysteine * MeSH
- Rats MeSH
- Lactates metabolism MeSH
- Cerebral Cortex metabolism MeSH
- Animals, Newborn metabolism MeSH
- Rats, Wistar MeSH
- Seizures chemically induced metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenosine Triphosphate MeSH
- Phosphocreatine MeSH
- Glucose MeSH
- Glycogen MeSH
- Homocysteine * MeSH
- Lactates MeSH
Seizures were induced in 7-day-old rats by intraperitoneal injection of DL-homocysteine thiolactone. Phosphocreatine (PCr), ATP, glucose, glycogen and lactate were determined in the cerebral cortex during various intervals after injection, corresponding to the early, as well as long periods of seizure activity. The unchanged levels of ATP, a very mild PCr decline and a pronounced accumulation of lactate (in the face of modest changes in brain glucose and glycogen) were observed. These results suggest that the immature rat brain is able to compensate energy expenditure associated with seizure activity by increased energy production, mainly due to increased anaerobic glycolysis. It remains to be determined whether a similar conclusion is also valid for other brain regions, e.g. subcortical structures.
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
