Age-dependent changes of baroreflex efficiency in Dahl rats: effects of high salt intake
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8218156
Knihovny.cz E-resources
- MeSH
- Baroreflex drug effects physiology MeSH
- Phenylephrine pharmacology MeSH
- Genotype MeSH
- Rats, Inbred Strains MeSH
- Blood Pressure physiology MeSH
- Rats MeSH
- Sodium, Dietary pharmacology MeSH
- Heart Rate physiology MeSH
- Aging physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Phenylephrine MeSH
- Sodium, Dietary MeSH
The age-dependent changes in baroreflex control of heart rate were studied in inbred Dahl rats. At the age of 8 weeks the baroreflex slope was significantly greater in salt-resistant (R/Jr) than in salt-sensitive (S/Jr) rats fed a low-salt diet. The reverse was true in 16-week-old animals. High salt intake (8% NaCl diet for 4 weeks) suppressed baroreflex efficiency in both age groups of S/Jr animals whereas no effects occurred in R/Jr rats. Baroreflex slope was, however, significantly lower in young S/Jr rats with a severe form of salt hypertension than in adult salt-loaded S/Jr rats in which only a moderate blood pressure elevation was observed.
Altered Balance between Vasoconstrictor and Vasodilator Systems in Experimental Hypertension
