Netropsin inhibits the increase of intracellular Ca(2+)-dependent serine proteinase activity in sporulating Bacillus megaterium
Language English Country United States Media print
Document type Journal Article
PubMed
8388845
DOI
10.1007/bf02814541
Knihovny.cz E-resources
- MeSH
- Bacillus megaterium drug effects enzymology MeSH
- Morphogenesis drug effects MeSH
- Netropsin pharmacology MeSH
- Gene Expression Regulation, Enzymologic drug effects MeSH
- Serine Endopeptidases biosynthesis drug effects MeSH
- Spores, Bacterial drug effects MeSH
- Calcium metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Netropsin MeSH
- Serine Endopeptidases MeSH
- Calcium MeSH
Netropsin suppressed the increase of intracellular proteolytic activity when added to B. megaterium incubated in a sporulation medium. The inhibited enzyme was a Ca(2+)-dependent serine proteinase. Sporulation and protein turnover in later sporulation phases were inhibited as well. Different concentrations of netropsin affected various aspects of protein catabolism differently.
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