Postirradiation administration of adenosine monophosphate combined with dipyridamole reduces early cellular damage in mice
Language English Country Netherlands Media print
Document type Journal Article
PubMed
8412492
DOI
10.1016/0024-3205(93)90577-p
PII: 0024-3205(93)90577-P
Knihovny.cz E-resources
- MeSH
- Adenosine Monophosphate pharmacology MeSH
- Whole-Body Irradiation MeSH
- Dipyridamole pharmacology MeSH
- Hydrocortisone pharmacology MeSH
- Mice, Inbred C57BL MeSH
- Mice, Inbred CBA MeSH
- Mice MeSH
- DNA Damage drug effects MeSH
- Radiation-Protective Agents pharmacology MeSH
- Thymidine blood MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Adenosine Monophosphate MeSH
- Dipyridamole MeSH
- Hydrocortisone MeSH
- Radiation-Protective Agents MeSH
- Thymidine MeSH
The administration of dipyridamole and adenosine 5'-monophosphate (AMP) to mice 5 to 25 min after 1 Gy of total-body gamma irradiation was found to decrease cellular damage, as indicated by the thymidine level in plasma and the amount of saline soluble polynucleotides in the thymus. The drug combination used did not influence similar cytotoxic effects of hydrocortisone. Furthermore, it was shown that the addition of dipyridamole and AMP to in vitro irradiated suspensions of thymocytes enhanced the rejoining processes of DNA strand breaks. Receptor-mediated action of extracellular adenosine may be responsible for the therapeutic effects observed.
References provided by Crossref.org
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