Detoxication products of the carcinogenic azodye Sudan I (solvent yellow 14) bind to nucleic acids after activation by peroxidase
Language English Country Ireland Media print
Document type Journal Article
PubMed
8422648
DOI
10.1016/0304-3835(93)90217-w
PII: 0304-3835(93)90217-W
Knihovny.cz E-resources
- MeSH
- Coloring Agents metabolism MeSH
- Biotransformation MeSH
- DNA metabolism MeSH
- Carcinogens metabolism MeSH
- Horseradish Peroxidase metabolism MeSH
- Rats MeSH
- Inactivation, Metabolic MeSH
- Naphthols metabolism MeSH
- Hydrogen Peroxide metabolism MeSH
- RNA, Transfer metabolism MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- 1-phenylazo-2-naphthol MeSH Browser
- Coloring Agents MeSH
- DNA MeSH
- Carcinogens MeSH
- Horseradish Peroxidase MeSH
- Naphthols MeSH
- Hydrogen Peroxide MeSH
- RNA, Transfer MeSH
The C-hydroxyderivatives of the carcinogenic dye Sudan I, 1-phenylazo-2,6-dihydroxynaphthalene and 1-(4-hydroxyphenylazo)-2-hydroxynaphthalene, which are considered to be detoxication products of this dye bind to DNA or tRNA after oxidation into active metabolites by peroxidase and H2O2 in vitro. The 32P-postlabeling analysis of DNA modified by active metabolites of both Sudan I derivatives provides evidence that the covalent binding to DNA is the principal type of DNA modification. Since the urinary bladder is rich in peroxidases, the participation of these enzymes in activation of detoxicating products of Sudan I may be involved in the initiation of Sudan I-carcinogenesis in this organ.
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