Detoxication products of the carcinogenic azodye Sudan I (solvent yellow 14) bind to nucleic acids after activation by peroxidase
Jazyk angličtina Země Irsko Médium print
Typ dokumentu časopisecké články
PubMed
8422648
DOI
10.1016/0304-3835(93)90217-w
PII: 0304-3835(93)90217-W
Knihovny.cz E-zdroje
- MeSH
- barvicí látky metabolismus MeSH
- biotransformace MeSH
- DNA metabolismus MeSH
- karcinogeny metabolismus MeSH
- křenová peroxidasa metabolismus MeSH
- krysa rodu Rattus MeSH
- metabolická inaktivace MeSH
- naftoly metabolismus MeSH
- peroxid vodíku metabolismus MeSH
- RNA transferová metabolismus MeSH
- techniky in vitro MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- 1-phenylazo-2-naphthol MeSH Prohlížeč
- barvicí látky MeSH
- DNA MeSH
- karcinogeny MeSH
- křenová peroxidasa MeSH
- naftoly MeSH
- peroxid vodíku MeSH
- RNA transferová MeSH
The C-hydroxyderivatives of the carcinogenic dye Sudan I, 1-phenylazo-2,6-dihydroxynaphthalene and 1-(4-hydroxyphenylazo)-2-hydroxynaphthalene, which are considered to be detoxication products of this dye bind to DNA or tRNA after oxidation into active metabolites by peroxidase and H2O2 in vitro. The 32P-postlabeling analysis of DNA modified by active metabolites of both Sudan I derivatives provides evidence that the covalent binding to DNA is the principal type of DNA modification. Since the urinary bladder is rich in peroxidases, the participation of these enzymes in activation of detoxicating products of Sudan I may be involved in the initiation of Sudan I-carcinogenesis in this organ.
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