Utilization of interleukin-2 gene transfer in local immunotherapy of cancer
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8440741
DOI
10.1007/bf01212720
Knihovny.cz E-resources
- MeSH
- Killer Cells, Natural drug effects physiology MeSH
- DNA genetics MeSH
- Immunotherapy * MeSH
- Interleukin-2 biosynthesis genetics MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Cell Transformation, Neoplastic genetics MeSH
- Tumor Cells, Cultured MeSH
- Neoplasms therapy MeSH
- Plasmacytoma genetics MeSH
- Spleen cytology immunology MeSH
- Transfection * MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- DNA MeSH
- Interleukin-2 MeSH
It has been previously found that local administration of Balb/c plasmacytoma cells transformed and made non-tumorigenic by insertion of the cloned murine interleukin-2 (IL-2) gene induced regressions of a variety of murine tumours including the original Balb/c plasmacytoma X63-Ag8.653 growing in syngeneic mice. The tumour-inhibitory effect of the plasmacytoma cells transformed by IL-2 cDNA and designated as X63-m-IL-2 was due to their high constitutive production of IL-2. Here we show that admixture of syngeneic spleen cells to the X63-m-IL-2 transformants substantially (P < 0.025) increased the antitumour efficacy of the transformants. Balb/c spleen cells co-cultivated with X63-m-IL-2 cells in vitro yielded predominantly Thy 1.2+, CD3+, LFA-1+ lymphocytes, cytolytic for the X63-Ag8.653 plasmacytoma as well as for other murine tumours, including the X63-m-IL-2 target cells.
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