Distribution of non-class-III beta-tubulin isoforms in neuronal and non-neuronal cells
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články
PubMed
8462682
DOI
10.1016/0014-5793(93)81662-j
PII: 0014-5793(93)81662-J
Knihovny.cz E-zdroje
- MeSH
- buňky 3T3 MeSH
- druhová specificita MeSH
- elektroforéza v polyakrylamidovém gelu MeSH
- fibroblasty metabolismus MeSH
- HeLa buňky MeSH
- kultivované buňky MeSH
- lidé MeSH
- mozek metabolismus MeSH
- myši MeSH
- neuroblastom MeSH
- neurony metabolismus MeSH
- posttranslační úpravy proteinů MeSH
- tubulin metabolismus MeSH
- western blotting MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- tubulin MeSH
beta-Tubulin isoforms in brain tissues and in cell lines were analyzed by high-resolution isoelectric focusing in combination with monoclonal antibodies. Post-translational modifications of brain non-class-III beta-tubulin isoforms were found in phylogenetically distant species ranging from pig to carp. Less extensive modifications were also observed in Neuro-2a, HeLa and 3T3 cells, where most acidic isoforms were glutamylated, while the basic, most abundant isoforms were not. The data suggest post-translational modification of non-class-III beta-tubulin isoforms in neuronal as well as in non-neuronal cells. Such modification might modulate interaction of tubulin with microtubule-associated proteins.
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