Slow potential recording was used for long-term monitoring of the penumbra zone surrounding an ischemic region produced by middle cerebral artery (MCA) occlusion in adult hooded rats (n = 32). Four capillary electrodes (El-E4) were chronically implanted at 2-mm intervals from AP -3, L 2 (El) to AP 0, L 5 (E4). Spontaneous or evoked slow potential waves of spreading depression (SD) were recorded during and 4 h after a 1-h MCA occlusion and at 2- to 3-day intervals afterward for 3 weeks. Duration of the initial focal ischemic depolarization was maximal at E4 and decreased with distance from the focus. SD waves in the penumbra zone were high at El and E2, low and prolonged at E3, and almost absent at E4. Amplitude of elicited SD waves was further reduced 3 days later and slowly increased in the following week. Cortical areas displaying marked reduction of SD waves in the first days after MCA occlusion either remained low or showed substantial (60%) recovery, the probability of which decreased with the duration of the initial focal ischemic depolarization and increased with the distance from the focus. It is concluded that the outcome of ischemia monitored by long-term SD recovery in the perifocal region can be partly predicted from the acute signs of MCA occlusion.

Institute of Physiology Academy of Sciences Czech Republic

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Electroencephalogr Clin Neurophysiol. 1987 Apr;66(4):440-7 PubMed

An Acad Bras Cienc. 1984 Dec;56(4):495-504 PubMed

Pflugers Arch Gesamte Physiol Menschen Tiere. 1957;264(4):325-34 PubMed

Brain Res. 1972 Apr 14;39(1):255-9 PubMed

Brain Res. 1987 Dec 29;437(2):360-4 PubMed

J Cereb Blood Flow Metab. 1994 Jan;14(1):12-9 PubMed

Physiol Rev. 1985 Jan;65(1):101-48 PubMed

Brain Res. 1988 Aug 9;457(2):226-40 PubMed

J Cereb Blood Flow Metab. 1986 Oct;6(5):607-15 PubMed

J Cereb Blood Flow Metab. 1992 Sep;12(5):727-33 PubMed

Am J Physiol. 1953 Apr;173(1):171-5 PubMed

Neurochem Pathol. 1988 Jul-Dec;9:195-209 PubMed

J Neurosci. 1991 Apr;11(4):1049-56 PubMed

Acta Neurol Scand. 1988 Feb;77(2):81-101 PubMed

Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1957;231(6):550-61 PubMed

Brain Res. 1990 Jun 11;519(1-2):351-4 PubMed

J Cereb Blood Flow Metab. 1992 Mar;12(2):223-9 PubMed

Brain Res. 1993 Mar 26;606(2):251-8 PubMed

J Cereb Blood Flow Metab. 1989 Apr;9(2):127-40 PubMed

J Cereb Blood Flow Metab. 1991 Jan;11(1):88-98 PubMed

Am J Physiol. 1964 Oct;207:921-4 PubMed

J Cereb Blood Flow Metab. 1994 Mar;14(2):301-11 PubMed

J Cereb Blood Flow Metab. 1988 Oct;8(5):757-62 PubMed

J Cereb Blood Flow Metab. 1992 May;12(3):371-9 PubMed

J Cereb Blood Flow Metab. 1994 Jan;14(1):20-8 PubMed

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