Fasting-related hyperbilirubinemia in rats: the effect of decreased intestinal motility
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8698202
DOI
10.1053/gast.1996.v111.pm8698202
PII: S0016508596003204
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Bilirubin blood metabolism MeSH
- Feces chemistry MeSH
- Gastrointestinal Motility * MeSH
- Gastrointestinal Transit MeSH
- Glutathione Transferase metabolism MeSH
- Hyperbilirubinemia etiology metabolism physiopathology MeSH
- Liver metabolism MeSH
- Rats MeSH
- Fasting adverse effects metabolism physiology MeSH
- Rats, Gunn MeSH
- Rats, Wistar MeSH
- Intestines physiopathology MeSH
- Intestinal Mucosa metabolism MeSH
- Urobilinogen metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Bilirubin MeSH
- Glutathione Transferase MeSH
- Urobilinogen MeSH
BACKGROUND & AIMS: Fasting increases serum bilirubin levels in both humans and rats. Because the pathogenesis of fasting hyperbilirubinemia is not fully understood, the effect of fasting on disposition of bile pigments was investigated in rats. METHODS: Bilirubin and urobilinogen were determined in excreta, bile, plasma, and liver tissues of fasted Gunn and Wistar rats. RESULTS: Fasting increased the intestinal transit time of Wistar rats. As a result, the fecal output of bile pigments was decreased by food deprivation. In contrast, the intestinal content of total bile pigments was augmented in both Wistar and Gunn rats. This finding was paralleled by the increase of serum bilirubin concentration in both rat strains. A similar increment of serum bilirubin levels was observed after injection of bilirubin into the cecum of Wistar rats. Furthermore, biliary efflux of bilirubin in Wistar rats was increased after 48 hours of fasting. Intubation of nonabsorbable bulk to fasted Wistar rats prevented the increase of serum bilirubin levels during a 48-hour period of food deprivation. CONCLUSIONS: Fasting decreases intestinal motility and elimination of bile pigments. Accumulation of bilirubin in the intestine during fasting allows enhanced enterohepatic circulation and results in an increased reflux to plasma. This seems to be a major factor involved in fasting-induced hyperbilirubinemia.
References provided by Crossref.org
The physiology of bilirubin: health and disease equilibrium
