Accumulation of activated lymphocytes in liver of Listeria factor Ei treated rabbits
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8768256
DOI
10.1007/bf02818524
Knihovny.cz E-resources
- MeSH
- Lymphocyte Activation drug effects MeSH
- Biological Factors immunology pharmacology MeSH
- Liver immunology MeSH
- Rabbits MeSH
- Kidney immunology MeSH
- Listeria monocytogenes immunology MeSH
- Lymphocyte Count drug effects MeSH
- Lymphocyte Subsets drug effects immunology MeSH
- Spleen immunology MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biological Factors MeSH
- Listeria monocytogenes factor Ei MeSH Browser
Factor Ei isolated from Listeria monocytogenes caused in rabbits 1 d after intravenous administration activation of peripheral blood lymphocytes in terms of rRNA biosynthesis. Increase of the number of these active lymphocytes was observed not only in peripheral blood, but also in spleen, lung, kidney, and liver. when the number of lymphocytes was related to the amount of the organ tissue cells, the increment appeared significant only in the liver where the number of active lymphocytes exceeded the control value by one order of magnitude. Based upon this observation we concluded that the accumulation of Listeria factor Ei activated lymphocytes occurred in liver. This characteristic is considered an additional immunomodulative property of Listeria factor Ei similar to the Escherichia coli lipopolysaccharide.
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