We have constructed a genetic linkage map in the rat by analyzing the strain distribution patterns of 500 genetic markers in a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown-Norway rat (HXB and BXH recombinant inbred strains). 454 of the markers could be assigned to specific chromosomes, and the amount of genome covered by the mapped markers was estimated to be 1151 centimorgans. By including a variety of morphologic, biochemical, immunogenetic, and molecular markers, the current map integrates and extends existing linkage data and should facilitate rat gene mapping and genetic studies of hypertension and other complex phenotypes of interest in the HXB and BXH recombinant inbred strains.

Institute of Physiology Czech Academy of Sciences Prague

See more in PubMed

Psychopharmacology (Berl). 1991;104(4):413-24 PubMed

Behav Genet. 1992 Nov;22(6):677-84 PubMed

Hypertension. 1992 Jun;19(6 Pt 2):611-4 PubMed

J Hered. 1984 Jul-Aug;75(4):313 PubMed

Genomics. 1993 Jun;16(3):761-4 PubMed

Acta Univ Carol Med Monogr. 1975;(68):1-103 PubMed

Behav Genet. 1992 Nov;22(6):665-76 PubMed

Genomics. 1991 Sep;11(1):135-44 PubMed

Mamm Genome. 1993;4(6):303-13 PubMed

Nat Genet. 1992 Jul;1(4):267-72 PubMed

Mamm Genome. 1994 Jun;5(6):361-4 PubMed

Transplant Proc. 1990 Dec;22(6):2588-9 PubMed

Hypertension. 1991 Feb;17(2):242-6 PubMed

Mamm Genome. 1994 Mar;5(3):153-9 PubMed

Genetics. 1990 Sep;126(1):277-84 PubMed

EXS. 1993;67:47-57 PubMed

Nat Genet. 1995 Jan;9(1):63-9 PubMed

Biochem Genet. 1994 Jun;32(5-6):147-54 PubMed

Nat Genet. 1993 Apr;3(4):346-53 PubMed

Transplant Proc. 1993 Oct;25(5):2777 PubMed

J Hered. 1985 Nov-Dec;76(6):436-40 PubMed

Biochem Genet. 1986 Apr;24(3-4):217-27 PubMed

Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5408-12 PubMed

J Immunogenet. 1987 Apr-Jun;14(2-3):163-76 PubMed

Nucleic Acids Res. 1987 Apr 10;15(7):2823-36 PubMed

Cytogenet Cell Genet. 1993;63(2):117-23 PubMed

Genomics. 1992 Feb;12(2):350-6 PubMed

J Clin Invest. 1994 Jun;93(6):2701-9 PubMed

Genomics. 1992 Mar;12(3):454-8 PubMed

Behav Genet. 1991 Mar;21(2):99-116 PubMed

Nat Genet. 1994 Jun;7(2 Spec No):220-45 PubMed

Genomics. 1993 Nov;18(2):277-82 PubMed

Lab Anim. 1983 Jul;17(3):221-4 PubMed

J Clin Invest. 1995 Oct;96(4):1973-8 PubMed

Mamm Genome. 1994 Feb;5(2):63-83 PubMed

Genomics. 1995 May 1;27(1):149-54 PubMed

Mamm Genome. 1992;3(11):656-8 PubMed

Transplant Proc. 1990 Dec;22(6):2557-8 PubMed

Electrophoresis. 1991 Feb-Mar;12(2-3):134-40 PubMed

Mamm Genome. 1993;4(5):239-42 PubMed

Mamm Genome. 1993;4(3):135-40 PubMed

Nucleic Acids Res. 1989 Oct 11;17(19):7623-30 PubMed

J Hypertens. 1989 Mar;7(3):217-21 PubMed

Science. 1994 Jun 17;264(5166):1715-23 PubMed

Genomics. 1994 Jan 1;19(1):190-1 PubMed

Genetics. 1992 Jul;131(3):701-21 PubMed

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