In vitro susceptibility of pneumococci to trovafloxacin, penicillin G, and other antimicrobial agents in the Czech Republic and Slovakia
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8894582
DOI
10.1007/bf01691161
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents pharmacology MeSH
- Fluoroquinolones * MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Naphthyridines pharmacology MeSH
- Penicillin G pharmacology MeSH
- Penicillins pharmacology MeSH
- Streptococcus pneumoniae drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Infective Agents MeSH
- Fluoroquinolones * MeSH
- Naphthyridines MeSH
- Penicillin G MeSH
- Penicillins MeSH
- trovafloxacin MeSH Browser
The in vitro activity of the new naphthyridone trovafloxacin (CP 99,219) was compared with those of penicillin G and six other agents (cefpodoxime, erythromycin, azithromycin, clindamycin, ciprofloxacin, and sparfloxacin) against 316 penicillin-susceptible and -resistant pneumococci isolated in the former Czechoslovakia. Trovafloxacin was very active against strains of Streptococcus pneumoniae (MIC50 and MIC90 0.25 microgram/ml). Ciprofloxacin was less active (MIC50 1.0 microgram/ml, MIC90 2.0 micrograms/ml), and MICs of sparfloxacin were between those of trovafloxacin and ciprofloxacin (MIC50 and MIC90 both 0.5 microgram/ml). MICs of cefpodoxime, erythromycin, azithromycin, and clindamycin were higher for strains intermediately resistant or resistant to penicillin than for penicillin-susceptible strains.
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