In vitro susceptibility of 90 penicillin-susceptible and -resistant pneumococci to penicillin G, amoxicillin, amoxicillin/clavulanate, cefaclor, cefuroxime, cefpodoxime, cefixime and imipenem
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu srovnávací studie, časopisecké články
PubMed
9569631
DOI
10.1007/bf02815546
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky farmakologie MeSH
- cefalosporiny farmakologie MeSH
- laktamy farmakologie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- penicilin G farmakologie MeSH
- peniciliny farmakologie MeSH
- pneumokokové infekce mikrobiologie MeSH
- rezistence na penicilin * MeSH
- Streptococcus pneumoniae účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- antibakteriální látky MeSH
- cefalosporiny MeSH
- laktamy MeSH
- penicilin G MeSH
- peniciliny MeSH
In vitro susceptibility of eight antibiotics was compared using three groups of pneumococci and agar dilution method comprising 30 penicillin-susceptible, 30 intermediately penicillin-resistant, and 30 highly penicillin-resistant pneumococci. Decreased sensitivity to all beta-lactam agents of intermediately penicillin-resistant and highly penicillin-resistant pneumococci is shown. MIC50 and MIC90 was lower with amoxicillin with and without clavulanate by one dilution than with penicillin. Cephalosporin MIC90s were all significantly higher for intermediately resistant and fully resistant strains. Only imipenem was more active than penicillin with MIC90 of susceptible pneumococci 0.015 mg/L, intermediately resistant pneumococci 0.25 mg/L, resistant pneumococci 1 mg/L.
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