7Beta-OH-DHEA counteracts dexamethasone induced suppression of primary immune response in murine spleenocytes
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
10659701
DOI
10.1016/s0960-0760(99)00134-x
PII: S0960-0760(99)00134-X
Knihovny.cz E-zdroje
- MeSH
- buňky produkující protilátky cytologie účinky léků imunologie MeSH
- dehydroepiandrosteron aplikace a dávkování analogy a deriváty farmakologie MeSH
- dexamethason antagonisté a inhibitory farmakologie MeSH
- hemolytická plaková technika MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- slezina cytologie účinky léků imunologie MeSH
- techniky in vitro MeSH
- viabilita buněk účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- 7-hydroxydehydroepiandrosterone MeSH Prohlížeč
- dehydroepiandrosteron MeSH
- dexamethason MeSH
The effect of dexamethasone and of three potential antiglucocorticoids, namely dehydroepiandrosterone (DHEA) and its 7alpha-and 7beta-hydroxylated metabolites, on primary immune response has been studied by measuring the number of plaque forming cells (NPFC) and their viability in a cell culture of murine spleenocytes. As expected, dexamethasone suppressed considerably the NPFC as well as their viability. Surprisingly, DHEA as well as its 7alpha-hydroxylated metabolite decreased significantly the NPFC, while the effect of 7beta-hydroxy-DHEA was different: at low doses it decreased the NPFC, but this effect was less pronounced at higher concentrations. In addition, 7beta-hydroxy-DHEA was able to counteract the effect of dexamethasone on the NPFC. None of the natural steroids affected the cell viability.
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