In vitro susceptibility of 90 penicillin-susceptible and -resistant pneumococci to penicillin G, amoxicillin, amoxicillin/clavulanate, cefaclor, cefuroxime, cefpodoxime, cefixime and imipenem
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
9569631
DOI
10.1007/bf02815546
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Cephalosporins pharmacology MeSH
- Lactams pharmacology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Penicillin G pharmacology MeSH
- Penicillins pharmacology MeSH
- Pneumococcal Infections microbiology MeSH
- Penicillin Resistance * MeSH
- Streptococcus pneumoniae drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Cephalosporins MeSH
- Lactams MeSH
- Penicillin G MeSH
- Penicillins MeSH
In vitro susceptibility of eight antibiotics was compared using three groups of pneumococci and agar dilution method comprising 30 penicillin-susceptible, 30 intermediately penicillin-resistant, and 30 highly penicillin-resistant pneumococci. Decreased sensitivity to all beta-lactam agents of intermediately penicillin-resistant and highly penicillin-resistant pneumococci is shown. MIC50 and MIC90 was lower with amoxicillin with and without clavulanate by one dilution than with penicillin. Cephalosporin MIC90s were all significantly higher for intermediately resistant and fully resistant strains. Only imipenem was more active than penicillin with MIC90 of susceptible pneumococci 0.015 mg/L, intermediately resistant pneumococci 0.25 mg/L, resistant pneumococci 1 mg/L.
See more in PubMed
Bratisl Lek Listy. 1983 Aug;80(2):176-84 PubMed
J Antimicrob Chemother. 1996 Jul;38 Suppl A:117-32 PubMed
Antimicrob Agents Chemother. 1996 Feb;40(2):481-4 PubMed
Eur J Clin Microbiol Infect Dis. 1996 Aug;15(8):686-8 PubMed
J Infect Dis. 1989 Jan;159(1):16-25 PubMed
Eur J Clin Microbiol Infect Dis. 1995;14 Suppl 1:S18-25 PubMed
Microb Drug Resist. 1995 Spring;1(1):29-34 PubMed
J Antimicrob Chemother. 1991 Apr;27(4):405-25 PubMed
J Antimicrob Chemother. 1992 Sep;30(3):279-88 PubMed
Chemotherapy. 1997 Sep-Oct;43(5):316-22 PubMed
Clin Infect Dis. 1992 Jul;15(1):77-83 PubMed
