Melatonin instantaneously resets intrinsic circadian rhythmicity in the rat suprachiasmatic nucleus
Language English Country Ireland Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8945758
DOI
10.1016/s0304-3940(96)13159-1
PII: S0304394096131591
Knihovny.cz E-resources
- MeSH
- Circadian Rhythm drug effects MeSH
- Injections, Subcutaneous MeSH
- Rats MeSH
- Melatonin pharmacology MeSH
- Suprachiasmatic Nucleus drug effects metabolism physiology MeSH
- Rats, Wistar MeSH
- Proto-Oncogene Proteins c-fos immunology metabolism MeSH
- Light MeSH
- Darkness MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Melatonin MeSH
- Proto-Oncogene Proteins c-fos MeSH
In order to follow resetting of the rat circadian pacemaking system by melatonin in vivo, the rhythm in the light-induced c-fos expression was used as a marker of the intrinsic rhythmicity of the suprachiasmatic nucleus (SCN). A single melatonin administration during late day to rats maintained originally under a short photoperiod with 8 h of light per day or under a long photoperiod with 16 h of light per day phase advanced immediately the evening rise in the light-induced SCN c-Fos immunochemistry by about 1.5 h. The data indicate that melatonin administration in vivo may instantaneously reset the intrinsic SCN rhythmicity.
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