Prínos katepsinu B-like v monitorování chemicky indukovaného primárního cholangiokarcinomu veprů
[Cathepsin B-like substance in the monitoring of chemically induced primary cholangiocarcinoma in swine]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Research Support, Non-U.S. Gov't
PubMed
8967025
- MeSH
- Alkaline Phosphatase analysis MeSH
- Cholangiocarcinoma chemically induced diagnosis MeSH
- Glucuronidase analysis MeSH
- Isoenzymes analysis MeSH
- Carcinoembryonic Antigen analysis MeSH
- Cathepsin B analysis MeSH
- Biomarkers, Tumor analysis MeSH
- Bile Duct Neoplasms chemically induced diagnosis MeSH
- Swine MeSH
- Bile chemistry MeSH
- Bile Ducts, Intrahepatic * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Alkaline Phosphatase MeSH
- Glucuronidase MeSH
- Isoenzymes MeSH
- Carcinoembryonic Antigen MeSH
- Cathepsin B MeSH
- Biomarkers, Tumor MeSH
Activity of beta-glucuronidase (GL), placentar izoenzyme of alkaline phosphatase (PLAP), cathepsin B (CB) and concentrations of carcinoembryonic antigen (CEA) were determined in serums and bile of pigs with experimental cholangiocarcinoma and in control animals. No differences in serum GL, PLAP, CB activities or CEA were observed. The same was found in bile for GL, PLAP and CEA. However, in bile the situation was different for CB. In all the tumour bearing animals we were able to demonstrate in the course of tumour development a stricking progression in CB activity. Very impressive was namely an elevation of CB alkaline-stable form, generated (according also to the chromatographic studies of the bile) from primary cholangiocarcinoma tissue.
