Differences in response to activation of adenylyl cyclase by various stimulants in human myocardium
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
8974072
DOI
10.1007/bf00408673
Knihovny.cz E-zdroje
- MeSH
- adenylátcyklasy metabolismus MeSH
- aktivace enzymů MeSH
- dítě MeSH
- guanylylimidodifosfát farmakologie MeSH
- isoprenalin farmakologie MeSH
- kolforsin farmakologie MeSH
- lidé MeSH
- mladiství MeSH
- myokard enzymologie MeSH
- srdce účinky léků MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- adenylátcyklasy MeSH
- guanylylimidodifosfát MeSH
- isoprenalin MeSH
- kolforsin MeSH
The response of adenylyl cyclase complex in human atrial tissue removed at corrective surgery of normoxemic and hypoxemic congenital heart defects in children to various stimulants was evaluated and related to the oxygenation state of the myocardium. When comparing response to stimulation in normoxemic and hypoxemic atria a higher basal as well as stimulated adenylyl cyclase activity was found in hypoxemic atria; an insignificant stimulatory effect of isoprenaline in normoxemic hearts became significant in the atria of hypoxemic patients. Hypoxemic samples also showed two times higher activity when the total catalytic activity was evaluated by the stimulation with forskolin. Higher stimulatory effect of Gpp/NH/p was also observed in hypoxemic than in normoxemic state. Increased adenylyl cyclase activity might represent one of adaptive mechanisms to hypoxemia in patients with congenital heart defects.
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