Structural organization of the pre-mRNA splicing commitment: a hypothesis
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
8986648
DOI
10.1006/jsbi.1996.0082
PII: S1047-8477(96)90082-9
Knihovny.cz E-resources
- MeSH
- Models, Biological MeSH
- Cell Nucleus metabolism MeSH
- Molecular Structure MeSH
- RNA Precursors chemistry genetics metabolism MeSH
- RNA Splicing * MeSH
- Binding Sites MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- RNA Precursors MeSH
Several models have been presented in the past to explain localized distributions of nuclear RNAs from individual genes that range from small foci to more elongated "track-like" structures. We present here a hypothesis which explains that, in the case of regulated splicing, there is in diploid cells a spatial separation of transcription sites from the execution of regulated splicing which we situate to domains of SR protein accumulation. In addition, it explains the presence of poly(A) sequences, and the lack of the autoradiographic label due to short pulses of [3H]uridine, in these domains.
References provided by Crossref.org
Prespliceosomal assembly on microinjected precursor mRNA takes place in nuclear speckles
