Pharmacodynamic parameters of aminoglycosides and their effect on exoenzymes of Pseudomonas aeruginosa
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
9138310
DOI
10.1007/bf02814691
Knihovny.cz E-zdroje
- MeSH
- antibakteriální látky farmakologie MeSH
- endopeptidasy účinky léků metabolismus MeSH
- gentamiciny farmakologie MeSH
- mikrobiální testy citlivosti MeSH
- pankreatická elastasa účinky léků metabolismus MeSH
- Pseudomonas aeruginosa účinky léků enzymologie metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antibakteriální látky MeSH
- endopeptidasy MeSH
- gentamiciny MeSH
- pankreatická elastasa MeSH
Aminoglycosides at 2x or 4x minimum inhibitory concentration induced postantibiotic effects against Pseudomonas aeruginosa lasting 3.5-4.9 h (gentamicin) and 0.5-3.7 h (selemycin). Postantibiotic effects of subinhibitory concentrations of the aminoglycosides tested were substantially longer. Some combinations of supra- and subinhibitory concentrations of antibiotics did not even allow any regrowth of the bacterial strain. The postantibiotic effects and postantibiotic effects of subinhibitory concentrations of gentamicin and selemycin were associated with changes of P. aeruginosa elastase and proteinase. Combinations of supra- and subinhibitory concentrations more pronouncedly suppressed enzymic activities than did suprainhibitory concentrations alone.
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